In this article, we analyze social conditions of slum-dwellers in the Arab district of Malekshahr in Isfahan. We examine how these slum residents are considered “strangers” by Isfahan residents, inhabitants of the adjacent districts, and even themselves. Data for this study were collected through a mixed method in two phases. Each phase included in-depth interviews and a survey. Research findings indicate that due to low levels of social trust, insecurity, and lack of intimate and close social relations among residents, the social fabric of the Arab District is fragile and weak. Furthermore, negative attitudes toward slum residents expressed by inhabitants of neighboring districts, a strong emphasis on ethnic identity of the residents, and lack of powerful relations with individuals of high socioeconomic status have exacerbated the physical and social alienation of the Arab district of Malekshahr from the larger urban and social processes.